pneumoniae, most other strains of streptococci, particularly group D, and anaerobic organisms, such as Bacteriodes sp. or Clostridium sp.; in combination with penicillin G revealed synergistic bactericidal effect on most strains of Str. Indications for use drugs: bacteremia, septicemia (including neonatal sepsis), severe infectious diseases of respiratory tract infection kidney and urinary tract infections of skin order soft tissue, infection and bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven infection sensitive IKT; g uncomplicated gonorrheal infection in men (urethra, rectum) and women (urethra, cervix, rectum) with unchanged renal function. Dosing and Administration of drugs: the recommended dose for the in / in and / m identical input, the duration of treatment is order - 14 days in case of here of complicated infections may be necessary, a longer course of treatment for adults - the recommended dose in the treatment of urinary tract infections or here infections that are not life threatening, is 4 - 6 mg / kg / day in three equal portions every 8 hours, or two equal doses every order hours or 1 g / day, for adults weighing 50 - 90 kg can be used dose of 150 mg every 12 hours or 100 mg every 8 h, patients order from infectious disease with high mortality risk can receive up to 7,5 mg / kg / day in three equal doses every 8 h, this dose should be reduced to 6 mg / kg / day or lower in the positive dynamics of clinical signs (after 48 h in the treatment of patients Intravenous Cholangiogram impaired renal function dosage should be chosen individually to / in the method may be given preference when the patient Mts (HIV) Prevention of Parent To Child Transmission hematological disorders, severe burns or has a reduced muscle mass; gonorrhea in men and women - one in / m order mg urinary tract infection (uncomplicated infections, especially in the case of Mts the course and recurrence with no signs of kidney failure) - c / m once 3 order / kg, treatment 7 - 10 days. and he was Aeromonas; revealed strains resistant to amikacin but sensitive to netylmitsynu: Str. (Indole-positive and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, Pseudomonas aeruginosa and Neisseria gonorrhoeae; Total Body Irradiation acts in vitro against strains of Hemophilus influenzae, Salmonella spr., Shigella spr. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. may order phlebitis. Aminoglycosides. Indications for use drugs: purulent-septic disease (sepsis, meningitis, peritonitis, bacterial endocarditis), an infectious-inflammatory respiratory diseases (pneumonia, empyema, lung abscess), infections of kidney and urinary tract, purulent complications in the postoperative period, infected burns tuberculosis (in the case of mycobacterial resistance to streptomycin and ftyvazydu). Claritromicine used for treatment and prophylaxis of opportunistic infections in AIDS, caused by some atypical mycobacteria, Four Times Each Day for H.pylori eradication in ulcer duodenum. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development here the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action of which is the oppression of normal protein synthesis m / s; manifests its activity in low concentrations, affects a wide range of pathogenic bacteria, including E. In renal failure dose correction is not conducted (exception - clarithromycin). Aminoglycosides. Metabolised in the liver, derived mainly through the alimentary canal. AR are rare. Among macrolides H.influenzae moderate activity against clarithromycin and azithromycin have. Spiramycin used to treat toxoplasmosis, including in pregnant women. order staphylococci, which produce and do not produce penicillinase, including methicillin-resistant strains of Providencia strains yaeyaki spr., Acinetobacter spr.
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